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Puerarin is a flavonoid glycoside extracted from the leguminous plant Pueraria lobata, which has various pharmacological activities and health benefits. Its main features include:
Puerarin is a flavonoid glycoside extracted from the leguminous plant Pueraria lobata, which has various pharmacological activities and health benefits. Its main features include:
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Classification |
Describe |
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Chemical properties |
Isoflavones derivatives, white needle shaped crystals, slightly soluble in water, colorless or pale yellow in aqueous solution. |
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Pharmacological effects |
Antioxidant, anti-inflammatory, anti-tumor, enhances immunity, protects cardiovascular and cerebrovascular systems and the nervous system. |
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Clinical application |
Treatment of coronary heart disease, hypertension, diabetes, arteriosclerosis, retinopathy, etc. |
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Safety |
Demonstrated good toxicological evaluation of safety in mouse experiments |
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Bioaccumulation |
Oral absorption is relatively low, but after being made into a solid dispersion, the bioavailability and efficacy are enhanced |
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Pharmacokinetics |
After intravenous injection, as the dose increases, the elimination half-life of the drug gradually shortens and the distribution half-life prolongs |
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Storage conditions |
It should be stored in a room temperature, dark, moisture-proof, and sealed dry environment |
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Drug ingredients |
The main ingredients include daidzein, daidzein, daidzein-7,4 '- diglucoside, puerarin, and puerarin 7-xyloside. |
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Drug preparation method |
Puerarin imprinted microspheres and their solid-phase extraction can be prepared by precipitation polymerization method |
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Drug interactions |
Inhibit LPS induced expression of iNOS, COX-2, and CRP proteins. |
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Pharmaceutical preparations |
Pueraria products and puerarin preparations on the market mainly include instant Pueraria powder, Pueraria noodles, Pueraria milk, Pueraria bread and other health foods, as well as Pueraria injection, Pueraria glucose injection, Pueraria sodium chloride injection, Baoji pill and other drugs |
The advantages of puerarin mainly focus on the following three aspects:
Multiple pharmacological activities:
Puerarin has various biological activities such as antioxidant, anti-inflammatory, antithrombotic, and anticancer, making it widely applicable in the field of biological research.
High safety:
Due to its low incidence of adverse reactions, puerarin has been widely used in clinical practice and has received attention from scholars both domestically and internationally in recent years.
Extensive therapeutic potential:
Puerarin has shown significant effect in the treatment of cardiovascular diseases, diabetes and its complications, atherosclerosis and other chronic diseases
The functions of puerarin mainly focus on the following three aspects:
1. Cardiovascular protection: Puerarin can dilate coronary and cerebral arteries, improve blood circulation, reduce myocardial oxygen consumption, alleviate myocardial ischemia, and combat angina and arrhythmia.
2. Neuroprotection: Puerarin has various neuroprotective effects, such as reducing excitotoxicity of amino acids, inhibiting oxidative stress, antagonizing Ca ² ⁺ overload, and alleviating inflammatory reactions.
3. Antitumor effect: Studies have shown that puerarin has the ability to inhibit cancer cell proliferation and induce cancer cell apoptosis, therefore it has potential application value in the field of anti-cancer.
4. Regulation of metabolism: Puerarin can regulate blood sugar and blood lipid levels, improve insulin resistance, and has therapeutic advantages for diabetes and its complications.
The application of puerarin mainly focuses on the following three aspects:
Puerarin is widely used to treat cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, and myocardial infarction.
Puerarin injection can be used to reduce intraocular pressure, improve microcirculation in the eyes, and treat ophthalmic diseases such as glaucoma, retinal arteriovenous occlusion, and high myopia.
Puerarin has also shown good efficacy in treating sudden deafness.
Puerarin can be used in the daily diet of diabetes patients to reduce the level of inflammatory factors and improve the excretion of urinary micro protein.
Puerarin is also used for the treatment of alcoholism, liver protection, weight loss, anti atherosclerosis and other diseases.
Puerarin, due to its extensive pharmacological activity and safety, has shown great potential in many fields, especially in the treatment of cardiovascular and cerebrovascular diseases, diabetes and its complications.
The production of puerarin involves various methods and processes, and different technical routes can be adopted according to different needs and application scenarios. Here are several main details of puerarin production:
Fermentation method:
Production of puerarin through fermentation of fresh koji by Aspergillus niger. This method optimizes the optimal extraction process through orthogonal experiments, such as an inoculation amount of 5%, fermentation time of 60 hours, and suitable pH value.
High speed countercurrent chromatography:
Use high-speed countercurrent chromatography to separate and purify puerarin extract. The specific operation is to follow the system of ethyl acetate: n-butanol: water=2:1:3 (v/v), with the upper phase as the stationary phase and the lower phase as the mobile phase. After fully dissolving the puerarin extract, it is injected into the chromatograph for separation.
Plant Cell Engineering Method:
The use of plant cell engineering technology to produce puerarin is a relatively advanced method, but the specific process details have not been described in detail.
Water extraction and alcohol precipitation method:
This is a commonly used method in actual production, which extracts puerarin through water extraction and alcohol precipitation steps. Although this method has low efficiency and high energy consumption, it is easy to operate.
Solid state fermentation method:
Extracting puerarin from kudzu root residue using solid-state fermentation technology. By hydrolyzing kudzu root residue with cellulase and then extracting puerarin, the product yield can be significantly improved, but the cost is relatively high.
Spray drying method:
Puerarin microcapsules were prepared by spray drying method, and the wall materials were Arabic gum and β - cyclodextrin. This method is commonly used in the food industry and is also applicable for the preparation of microcapsules of puerarin.
Mechanochemical preparation technology:
This technology improves the solubility, cumulative dissolution, and bioavailability of puerarin through mechanochemical methods, simplifies production processes, and reduces costs.
Injection preparation:
The preparation method of puerarin injection includes mixing puerarin powder with pharmaceutically acceptable solubilizing substances evenly to increase the solubility of puerarin without changing its acidity and alkalinity, achieving the clinically required drug concentration.
Other extraction methods:
There are also methods for extracting puerarin from wastewater used in the production of kudzu powder, as well as new processes for extracting puerarin from wild kudzu roots.
These methods each have their own advantages and disadvantages, and choosing the appropriate production method needs to be determined based on specific production conditions, cost budgets, and product quality requirements.
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